Jump to: What to expect when switching | Weight loss comparison | How to switch safely | Take home message
You can switch from Wegovy (semaglutide) to Mounjaro (tirzepatide) under medical supervision, though you’ll need to start at a lower dose of Mounjaro and gradually increase it.
Research suggests Mounjaro may lead to greater average weight loss – 25% after one year compared to 16% with Wegovy.
In the UK, both medications are prescribed through private healthcare providers, with costs typically ranging from £200-£300 per month.
The NHS only provides Wegovy or Mounjaro through specialist weight management services in specific regions.
Medication-assisted weight loss with a future focus
Start with Mounjaro, transition to habit-based health with our support
What to expect when switching from Wegovy to Mounjaro
The transition between these medications requires careful medical oversight. If you’re currently on 2.4mg of Wegovy (the highest dose), you’ll likely need to start at either 2.5mg or 5mg of Mounjaro, depending on your individual health assessment.
During this transition period, you may notice changes in:
- Appetite control: Your hunger signals might fluctuate as your body adjusts to the new medication mechanism
- Side effects: You may experience different side effects as Mounjaro acts on both GLP-1 and GIP receptors, unlike Wegovy which only targets GLP-1
- Dosing schedule: Mounjaro uses a different dosing protocol, which your healthcare team will guide you through
Weight loss comparison: Wegovy vs Mounjaro
Clinical evidence demonstrates meaningful differences in weight loss outcomes between these medications:
Mounjaro (tirzepatide) results:
- Average weight loss: 25% after one year (SURMOUNT-1 trial)
- 92% of participants achieved >10% weight loss
- 84% achieved >15% weight loss
Wegovy (semaglutide) results:
- Average weight loss: 16% after one year (STEP-1 trial)
- 69% of participants achieved >10% weight loss
- 50% achieved >15% weight loss
Achieving over 10% weight loss is particularly significant as it’s associated with meaningful improvements in health outcomes, including reduced risk of type 2 diabetes and cardiovascular disease.
How to switch safely from Wegovy to Mounjaro
Switching from Wegovy to Mounjaro will have three stages:
1. Medical assessment
Your healthcare team will evaluate your:
- Current Wegovy dose and response
- Overall health status
- Previous side effects
- Weight loss progress
2. Transition period
- Allow 7 days between your last Wegovy dose and first Mounjaro injection
- Start at a lower Mounjaro dose (typically 2.5mg or 5mg)
- Monitor your response closely for 4-8 weeks
3. Ongoing support
- Regular check-ins with your healthcare team
- Lifestyle and nutrition guidance
- Side effect management support
Take home message
Switching from Wegovy to Mounjaro is possible and may offer enhanced weight loss results, but it requires careful medical supervision and a structured transition plan.
While Mounjaro shows promising weight loss outcomes in clinical trials, success depends on maintaining healthy lifestyle habits throughout the transition.
Second Nature’s medication programme
Second Nature provides Mounjaro as part of our Mounjaro weight-loss programme.
Why should you choose Second Nature over other medication providers if you’ve decided to try Mounjaro (assuming you’re eligible)?
For peace of mind.
Second Nature has worked with the NHS for over 6 years, providing weight-loss programmes across the UK.
While our Mounjaro weight-loss programme is private and not currently used by the NHS, we’ve built the programme focusing on scientific evidence, patient safety, and data security.
We hope that our 6+ years of working with the NHS and building a track record of effective weight-loss results will give you peace of mind to give us a try.
