Jump to: Clinical differences between medications | Weight loss comparison | How to switch medications safely | Take home message
You can switch from Ozempic to Mounjaro, but you’ll typically need to start at Mounjaro’s lowest dose (2.5mg) and gradually increase it under medical supervision.
The transition process usually takes 4-6 weeks as your body adjusts to Mounjaro’s dual-action.
Clinical research shows that Mounjaro can lead to significantly more weight loss than Ozempic – up to 13.1% versus 6.7% after 40 weeks of treatment.
For UK patients in 2025, switching between these medications requires careful planning and support. While both medications affect blood sugar and appetite, they work differently – Ozempic targets one hormone (GLP-1), while Mounjaro targets two (GLP-1 and GIP).
Medication-assisted weight loss with a future focus
Start with Mounjaro, transition to habit-based health with our support
Clinical differences between medications
Clinical research shows significant differences in effectiveness between these medications:
| Comparison Factor | Ozempic | Mounjaro |
|---|---|---|
| Average weight loss (40 weeks) | 6.7% | 13.1% (15mg dose) |
| Weekly injection | Yes | Yes |
| Maximum Dose | 1mg | 15mg |
| Hormones targeted | GLP-1 only | GLP-1 and GIP |
| Time to maximum Effect | 8-12 weeks | 20-24 weeks |
Mounjaro’s enhanced effectiveness comes from its innovative dual-action. Targeting both GLP-1 and GIP hormones lowers hunger and improves blood sugar more than targeting GLP-1 alone.
How to switch medications safely
The transition from Ozempic to Mounjaro involves several carefully managed steps:
- Initial consultation with our clinical team
- Personalised transition plan based on your current Ozempic dose
- The gradual introduction of Mounjaro, starting at 2.5mg
- Regular check-ins with our healthcare team
- Careful monitoring of appetite and side effects
During your transition, you might notice changes in:
- Appetite levels
- Energy patterns
- Side effect profile
- Weight loss rate
Our registered nutritionists and clinicians provide comprehensive support throughout this adjustment period, helping you navigate challenges while maintaining your progress.
Take home message
Weight-loss injections are most effective when combined with building healthy habits. They create a window of opportunity to establish sustainable healthy habits while lowering hunger and food noise.
Second Nature’s medication programme
Second Nature provides Mounjaro as part of our Mounjaro weight-loss programme.
Why should you choose Second Nature over other medication providers if you’ve decided to try Mounjaro (assuming you’re eligible)?
For peace of mind.
Second Nature has worked with the NHS for over 6 years, providing weight-loss programmes across the UK.
While our Mounjaro weight-loss programme is private and not currently used by the NHS, we’ve built the programmes focusing on scientific evidence, patient safety, and data security.
We hope that our 6+ years of working with the NHS and building a track record of effective weight-loss results will give you peace of mind to give us a try.
