Jump to: Why would you take Mounjaro and omeprazole together? | How does Mounjaro work? | Take home message
You can take Mounjaro with omeprazole if you’re living with obesity and gastroesophageal reflux disease (GERD), as there’s no evidence that the drugs directly inhibit the other’s function.
You won’t be prescribed Mounjaro if you’re living with GERD but are at a healthy BMI, as it may lead to unnecessary weight loss.
However, both medications can cause gastrointestinal side effects like nausea, constipation, and diarrhoea, so it’s possible taking the two together could make managing these side effects more challenging.
Still, the side effects of Mounjaro are often transient and reduce in severity after the body has adapted to the drug.
Additionally, lifestyle habits like eating a healthy diet and getting adequate sleep can help reduce the severity of side effects while on Mounjaro.
If you joined Second Nature’s Mounjaro weight-loss programme, our clinical team would analyse your situation before prescription approval, and you’d have access to a registered dietitian or nutritionist 5 days a week for ongoing support.
If you start taking Mounjaro alongside omeprazole, we recommend informing your doctor.
Why would you take Mounjaro and omeprazole together?
Omeprazole is used to treat gastroesophageal reflux disease (GERD), which is strongly associated with obesity and excess body fat.
Research has shown that people with a BMI over 30 have a 94% greater risk of developing GERD and its related symptoms compared to those with a BMI below 25.
Increased abdominal pressure and chronic inflammation are two reasons why people living with obesity may experience a greater risk of developing GERD.
Clinical studies have also shown a dose-dependent relationship between weight loss and GERD. This means that the more significant weight loss achieved, the greater the reduction in GERD-related symptoms.
Therefore, taking Mounjaro, which induces significant weight loss of up to 26%, could work synergistically with omeprazole to reduce GERD symptoms via different mechanisms.
Reducing body fat, particularly visceral fat, which secretes pro-inflammatory molecules linked to GERD, could lead to significant improvements for people living with GERD.
How does Mounjaro work?
Mounjaro supports weight loss by mimicking two hormones in the body, GLP-1 and GIP, that communicate with the brain’s appetite control centre, the hypothalamus, to lower hunger and food-seeking behaviour.
By lowering hunger and our desire to eat, Mounjaro helps us eat fewer calories to achieve a calorie deficit.
A calorie deficit is when we consume fewer calories than our body needs to fuel its essential functions, like digestion, blood flow, and brain function.
By creating a calorie deficit, our bodies will ‘burn’ the excess fat stored for energy, and we’ll lose weight.
Mounjaro also slows down the rate at which we digest food so that our stomach and gut send signals to the brain to signal the feeling of fullness.
So, Mounjaro supports weight loss by making us feel less hungry through two mechanisms:
Communicating with the brain’s appetite control centre
Slowing the rate that food is digested
Randomised controlled trials have shown that Mounjaro leads to an average weight loss of around 26% after one year.
Take home message
Weight-loss injections are most effective when combined with a healthier lifestyle. They can help kickstart weight loss while you commit to developing healthier habits.
Mounjaro and other weight loss injections, like Ozempic and Wegovy, can allow you to make lifestyle changes to support long-term weight loss.
These medications can help silence food-related thoughts and give you a boost of confidence with more immediate weight-loss results.
They can also buy you the time and headspace to understand why your body may have struggled to lose weight and build new long-term healthy habits.
The core focus of our medication programmes is to calm down the feeling of food noise, lower your cravings, and allow you to build healthier habits to keep the weight off for good.
The ultimate goal is to make losing weight feel second nature.
Second Nature’s medication programmes
Second Nature has two medication-supported programmes: a Wegovy weight-loss programme and a Mounjaro weight-loss programme.
Why should you choose Second Nature over other medication providers if you’ve decided to try Mounjaro or Wegovy (assuming you’re eligible)?
For peace of mind.
Second Nature has worked with the NHS for over 6 years, providing weight-loss programmes across the UK.
While our Wegovy and Mounjaro weight-loss programmes are private and not currently used by the NHS, we’ve built the programmes focusing on scientific evidence, patient safety, and data security.
We hope that our 6+ years of working with the NHS and building a track record of effective weight-loss results will give you peace of mind to give us a try.
