Jump to: What is aspirin? | What is Mounjaro? | Why take Mounjaro with aspirin? | Take home message
You can take Mounjaro with aspirin, as there are no known direct interactions between the medications.
However, Mounjaro and aspirin affect cardiovascular function, so it’s worth monitoring how you respond to the combination.
While the combination is generally considered safe, both medications can influence blood pressure and cardiovascular health differently.
Mounjaro may enhance aspirin’s effectiveness over time through weight loss, as research shows that obesity can reduce aspirin’s impact on our cardiovascular system.
If you’re currently taking aspirin for cardiovascular protection and are considering starting Mounjaro, it’s recommended that you tell your doctor.
What is aspirin?
Aspirin is one of the most commonly prescribed medications in the UK, particularly for preventing cardiovascular events in people with established heart disease or those at high risk.
Low-dose aspirin (75mg daily) works by reducing platelet aggregation, which helps prevent blood clots that could lead to heart attacks or strokes.
Research shows that aspirin can reduce the risk of cardiovascular events by 10-20% in those at high cardiovascular risk, particularly for secondary prevention.
However, the effectiveness of aspirin can be influenced by body weight, with studies showing that its cardiovascular protective effects may be reduced in people living with obesity.
Additionally, research has also shown that aspirin increases the risk of major bleeding due to its blood-thinning effect, with some studies showing worse mortality rates for those taking the medication compared to those not taking aspirin.
So, aspirin, like all medications, has its risks and rewards, which is why it’s worth staying in close contact with your healthcare team while taking medications, particularly if you’re going to combine aspirin with Mounjaro.
The relationship between obesity and aspirin effectiveness
Research shows that people living with obesity often show reduced responsiveness to once-daily low-dose aspirin.
This reduced effectiveness is measured through higher levels of specific blood markers that indicate aspirin’s impact on blood clotting, which are 3-5 times higher in people with obesity compared to those without.
What is Mounjaro?
Mounjaro is a dual-action weight-loss injection. It supports weight loss by mimicking two hormones, GLP-1 and GIP, that communicate with the brain’s appetite control centre, the hypothalamus, to lower hunger and food-seeking behaviour.
By lowering hunger and our desire to eat, Mounjaro helps us eat fewer calories to achieve a calorie deficit.
A calorie deficit occurs when we consume fewer calories than our body needs to fuel its essential functions, such as digestion, blood flow, and brain function.
By creating a calorie deficit, our bodies will ‘burn’ the excess fat stored for energy, and we’ll lose weight.
Mounjaro also slows down the rate at which we digest food so that our stomach and gut send signals to the brain to signal the feeling of fullness.
Research shows that Mounjaro leads to an average weight loss of around 26% after one year.
Why take Mounjaro with aspirin?
Research shows that obesity can reduce aspirin’s cardiovascular protective effects, but Mounjaro’s significant impact on weight loss might help improve aspirin’s effectiveness over time.
This could be particularly beneficial for people who haven’t responded well to aspirin treatment due to their weight.
Mounjaro has also been shown to reduce the risk of cardiovascular disease and major events like heart attacks and stroke, potentially reducing the need for aspirin prescriptions in the future.
While both medications can positively influence cardiovascular health through different mechanisms, the impact of their combination on our health is broadly unknown.
Mounjaro can lower blood pressure significantly, especially during the first few months of treatment or when increasing doses.
When combined with aspirin’s blood-thinning effects, regular monitoring becomes essential to ensure the optimal balance of these medications, particularly as your body composition changes when you lose weight.
While there are no direct interactions between Mounjaro and aspirin, it’s essential to:
- Monitor blood pressure regularly, as Mounjaro can lower blood pressure
- Be aware of potential bleeding risks from aspirin
- Report any unusual symptoms to your healthcare provider
- Maintain regular check-ups to assess the effectiveness of both medications
Take home message
While Mounjaro and aspirin can be taken together safely, the combination requires careful monitoring and regular communication with your healthcare provider.
The relationship between obesity, aspirin effectiveness, and cardiovascular health is complex.
Mounjaro’s weight-loss effects might enhance aspirin’s cardiovascular protective benefits over time.
Always discuss medication changes with your healthcare provider to ensure appropriate monitoring and personalised advice for your situation.
Second Nature’s medication programmes
Second Nature has two medication-supported programmes: a Wegovy weight-loss programme and a Mounjaro weight-loss programme.
Why should you choose Second Nature over other medication providers if you’ve decided to try Mounjaro or Wegovy (assuming you’re eligible)?
For peace of mind.
Second Nature has worked with the NHS for over 6 years, providing weight-loss programmes across the UK.
While our Wegovy and Mounjaro weight-loss programmes are private and not currently used by the NHS, we’ve built the programmes focusing on scientific evidence, patient safety, and data security.
We hope that our 6+ years of working with the NHS and building a track record of effective weight-loss results will give you peace of mind to give us a try.
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