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Do you need to take electrolytes while on Mounjaro?

Robbie Puddick
Written by

Robbie Puddick

Medically reviewed by

Fiona Moncrieff

3 min read
Last updated January 2025
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Jump to: Why might I need electrolytes? | Signs of electrolyte imbalance | Managing electrolytes on Mounjaro | Take home message

Most people taking Mounjaro (tirzepatide) don’t need electrolyte supplements if they maintain a balanced diet and stay hydrated.

However, some individuals might benefit from electrolyte supplements, particularly during the first few weeks of treatment when side effects like nausea or diarrhoea are more common.

Research suggests rapid weight loss, especially when accompanied by gastrointestinal symptoms, can affect your body’s electrolyte balance.

This effect isn’t unique to Mounjaro but is a consideration when losing weight.

Understanding when and how to manage our electrolytes can help optimise your experience on Mounjaro while supporting our overall health and well-being.

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Why might I need electrolytes on Mounjaro?

While Mounjaro doesn’t directly cause electrolyte imbalances, several factors during treatment might affect your electrolyte levels:

1. Reduced food intake: Mounjaro works partly by decreasing appetite, which might lead to consuming fewer electrolyte-rich foods.
2. Gastrointestinal effects: Some people experience nausea, vomiting, or diarrhoea, particularly in the first few weeks. These symptoms can affect electrolyte balance.
3. Changes in fluid balance: As your body adjusts to the medication and loses weight, your hydration needs might change.

Understanding electrolytes and their role

Think of electrolytes as our body’s electrical system managers. They are minerals that carry electrical charges and are essential for:

  • Maintaining proper hydration
  • Supporting nerve and muscle function
  • Regulating blood pressure
  • Balancing pH levels
  • Facilitating nutrient transport across cell membranes

The main electrolytes your body needs include sodium, potassium, magnesium, calcium, and chloride. Each plays a specific role in maintaining our health.

Signs of electrolyte imbalance

Knowing potential electrolyte imbalance symptoms can help you monitor your health while on Mounjaro.

Common signs include:

1. Muscle-related symptoms:

  • Cramps or spasms
  • Weakness
  • Twitching

2. General symptoms:

  • Fatigue
  • Headaches
  • Irregular heartbeat
  • Confusion or irritability

If you experience any of these symptoms, especially if they persist or worsen, contact your healthcare provider.

Managing electrolytes on Mounjaro

The best approach to maintaining electrolyte balance while on Mounjaro is through diet and proper hydration.

Here’s a practical strategy:

1 – Focus on electrolyte-rich foods

Include these nutrient-dense options in your meals:

  • Season your meals with sea salt: Rich in sodium, chloride, and magnesium
  • Leafy greens (200g serving): Rich in magnesium and potassium
  • Natural yoghurt (150g serving): Excellent source of calcium
  • Bananas (1 medium): Contains potassium and magnesium
  • Sweet potatoes (150g serving): High in potassium
  • Seeds (30g serving): Rich in magnesium and other minerals

2 – Stay properly hydrated

  • Aim for 2-2.5 litres of fluid daily
  • Increase intake during exercise or hot weather
  • Consider sugar-free electrolyte drinks if experiencing side effects

3 – Monitor your needs

Pay attention to:

  • How you feel when active and moving about
  • Any unusual muscle cramping
  • Your energy levels
  • Side effects from Mounjaro

When might you need supplementation?

Consider discussing electrolyte supplementation with your healthcare provider if you:

  • Experience prolonged gastrointestinal side effects
  • Consistently experience the signs of electrolyte imbalance discussed above
  • Have underlying health conditions affecting electrolyte balance

How to take electrolytes

The most convenient forms of electrolyte supplements come in powders that you can add to water to drink.

If you feel you want to experiment with electrolytes, try taking a sugar-free electrolyte drink in the morning with breakfast and monitor how you feel and whether you notice things improve.

Take home message

While most people on Mounjaro won’t need electrolyte supplements, maintaining proper electrolyte balance through diet and hydration is essential for our health.

Focus first on consuming electrolyte-rich foods and staying well hydrated. If you experience persistent symptoms of electrolyte imbalance, consider taking an electrolyte drink or supplement.

Remember that your needs may change throughout your Mounjaro journey, particularly during the initial weeks of treatment or as you increase your dose.

Second Nature’s medication programme

Second Nature provides Mounjaro as part of our Mounjaro weight-loss programme.

Why should you choose Second Nature over other providers, assuming you’re eligible?

For peace of mind.

Second Nature has worked with the NHS for over 6 years, providing weight-loss programmes across the UK.

While our Mounjaro weight-loss programme is private and not currently used by the NHS, we’ve built programmes focusing on scientific evidence, patient safety, and data security.

We hope that our 6+ years of working with the NHS and building a track record of effective weight-loss results will give you peace of mind to give us a try.

Medication-assisted weight loss with a future focus

Start with Mounjaro, transition to habit-based health with our support

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