Jump to: Understanding diarrhoea on Mounjaro | Evidence-based solutions | Hydration strategies | Prevention strategies | When to seek help | Take home message
A diet based on whole foods, proper hydration, and electrolyte balance effectively manages diarrhoea while taking Mounjaro.
Research shows this side effect affects approximately 15-17% of people taking Mounjaro, particularly when starting treatment or increasing doses.
Clinical evidence demonstrates that following a structured eating pattern with easily digestible whole foods can significantly reduce the frequency and severity of diarrhoea episodes during weight loss.
This approach works alongside Mounjaro’s effects on digestion while maintaining the medication’s effectiveness for weight management.
Understanding diarrhoea on Mounjaro
Mounjaro (tirzepatide) can trigger diarrhoea in two ways:
1. It slows down stomach emptying, which can sometimes lead to irregular bowel movements
2. It affects how your body processes nutrients, potentially leading to temporary digestive changes
The impact varies significantly between individuals. Some people experience minimal symptoms, while others might need more substantial dietary adjustments.
This variation is entirely normal and doesn’t affect the medication’s weight management benefits.
Evidence-based solutions for treating diarrhoea
Whole foods approach
The Second Nature balanced plate method provides an excellent framework for maintaining healthy digestion while on Mounjaro:
- 50% of your plate from well-cooked, easily digestible vegetables
- 25% from lean protein sources
- 25% from simple, digestible carbohydrates
- Include small portions of healthy fats with each meal
[balanced plate]
You may find eating more simple meals are easier to digest when experiencing diarrhoea, focus on these easily digestible whole foods:
Proteins:
- Chicken and lean beef
- Whitefish
- Eggs
- Live yoghurt
Carbohydrates:
- Rice
- Sourdough toast
- Crackers
Vegetables:
- Carrots (well-cooked)
- Sweet potatoes (baked or boiled)
- Squash (well-cooked)
- Green beans (steamed)
Fats:
- Avocado
- Extra virgin olive oil
- Nuts and seeds
Hydration strategies
Proper hydration is crucial when experiencing diarrhoea on Mounjaro.
We recommend:
- Drinking 2.5-3L of fluids daily
- Using electrolytes if diarrhoea persists
- Consume clear broths
- Avoid caffeine and alcohol
Signs you might need to use electrolytes:
- Increased thirst
- Headaches
- Muscle cramps
- Fatigue
- Light-headedness
Prevention strategies
Preventing diarrhoea while on Mounjaro is often more effective than treating it once it occurs. Research-supported prevention strategies include:
- Maintaining consistent meal times: Even with reduced appetite, eat 3 main meals a day, only including snacks if you need to (to boost protein intake, for example)
- Starting doses gradually: Work with your healthcare provider to adjust your dose slowly
- Planning hydration: Space fluid intake throughout the day
- Introducing new foods slowly: If increasing fibre intake, introduce a new fibre source gradually. So, add berries to your breakfast on Monday, then chia seeds on Friday.
- Monitoring trigger foods: Keep a food diary to identify problematic foods
When to seek help
Contact your healthcare provider immediately if you experience:
- Severe diarrhoea lasting more than 2 days
- Signs of dehydration (dark urine, dizziness, extreme thirst)
- Severe abdominal pain
- Blood in stools
- Fever above 38.5°C (101.3°F)
These symptoms might require a medical assessment and potentially adjusting your Mounjaro treatment plan.
Take home message
While diarrhoea can occur while taking Mounjaro, focusing on easily digestible whole foods, proper hydration, and electrolyte balance effectively manages this side effect.
Implementing these changes gradually while maintaining open communication with your healthcare team is key to success.
Remember that individual responses vary, and what works best for one person may need adjustment for another.
Second Nature’s medication programme
Second Nature provides Mounjaro as part of our Mounjaro weight-loss programme.
Why should you choose Second Nature over other providers, assuming you’re eligible?
For peace of mind.
Second Nature has worked with the NHS for over 6 years, providing weight-loss programmes across the UK.
While our Mounjaro weight-loss programme is private and not currently used by the NHS, we’ve built the programme focusing on scientific evidence, patient safety, and data security.
We hope that our 6+ years of working with the NHS and building a track record of effective weight-loss results will give you peace of mind to give us a try.
